In the modern world, rescue operations in seismic zones are a complex and responsible task that requires efficient planning and coordination. In this context, the application of cyber-physical systems creates new opportunities to improve the efficiency and speed of emergency response. The study investigates how cyber-physical systems can be integrated into rescue operations, as well as their advantages and limitations. The purpose of this research is to identify the potential of cyber-physical systems to improve the process of rescue operations in seismic zones. The article explores the possibilities and perspectives of using cyber-physical systems for conducting rescue operations in areas affected by earthquakes. Examples of successful use of cyber-physical systems in real situations are given, and the advantages and disadvantages of various technologies are analyzed. The efficiency of post-earthquake search and rescue operations in seismically active zones is mainly determined by the speed of detecting survivors and assessing the situation. Existing technologies—cyber-physical systems, thermal cameras, radar systems, and acoustic sensors—often face limitations due to the uncertainty of destruction structures and the failure of communication infrastructure. This article introduces a new model with the implementation of smart wristbands, which is a new cyber-physical system approach. The model ensures both the mapping of vital signs and the mapping of destruction topology through acoustic analysis based on real-time data exchange in a self-organizing mesh network of smart wristbands. The proposed model enhances decision support for rescue teams, creating a more resilient and highly prioritized search-and-rescue ecosystem for emergencies (pp.52-60) .